Real Madrid have had an extended rest, with their Champions League trip to Lyon not until February 22, ahead of Saturday's home match against promoted Levante.
Madrid have won all 11 of their home matches at the Santiago Bernabeu this season and Portuguese centre-back Pepe believes Mourinho is capable of reeling in Barcelona in the title race.
"The more they attack (Jose) Mourinho, the more we want to win," Pepe said.
Levante, two points above the relegation zone, drew 0-0 with Real earlier in the season but were thrashed 8-0 by them in the King's Cup and will be gunning for revenge.
Levante can take heart from the absence of Real's first-choice goalkeeper Iker Casillas, who is suspended after his red card in the 1-0 win at Espanyol last weekend.
Antonio Adan made his Madrid league debut after Casillas was sent off two minutes into the Espanyol game and the 23-year-old, who came through the ranks at Real, could start against Levante as Jerzy Dudek is still struggling with injury.
In other Saturday's matches, Valencia host Sporting Gijon and Atletico Madrid travel to Real Zaragoza with under-pressure coach Quique Sanchez Flores desperate for a win to save his job.
Atletico have lost their last four league matches to drop to 11th and are seven points off the top six.