Real Madrid midfielder Toni Kroos has been ruled out of Germany's upcoming fixtures and is a major doubt for the clasico against Barcelona after sustaining a thigh injury during the 4-2 win over Granada on Saturday.
A statement from Real said Kroos had injured his left thigh muscle but did not say for how long he would be out, while Spanish media reports said he would be out of action for three weeks.
This timescale would mean Kroos was certain to miss Germany's friendly with Argentina on Wednesday and their Euro 2020 qualifier against Estonia on Sunday as well as Real's league game at Real Mallorca on October 19 and the Uefa Champions League visit to Galatasaray on October 22.
He will then face a battle to be back in time for the clasico against Real's arch rivals Barcelona on October 26 at Camp Nou.